How Does Ketamine Compare to ECT in Treatment-Resistant Depression

This Study enrolled over 400 outpatients with Treatment-Resistant Depression( TRD ) without psychosis who had been refererd to ECT clinic. These patients were randomly assigned to receive either three weeks of ketamine or ECT. Most patients had moderate to severe depression that had lasted a median of two years and had not responded to antidepressant treatments. After three weeks of treatment, response rates were higher

for ketamine -55% vs 41% for ECT. At six months follow-

up, relapse rates were lower in the ketamine group (34% vs

56%).

https://pubmed.ncbi.nlm.nih.gov/37224232/